Professor, Distinguished Scholar and Acting Associate Dean, College of Agricultural, Life and Physical Sciences
Current research interests of the Goodson Group: NMR and MRI enjoy wide applicability but suffer from poor detection sensitivity. For this reason, imaging and spectroscopy of low-concentration species—such as gases in lung spaces or metabolites in tissues—can be particularly challenging. To combat such problems, we are pursuing two “hyperpolarization” methods: (1) spin-exchange optical pumping (SEOP), a technique whereby high-power lasers are used to prepare hyperpolarized noble gases (primarily for enhanced biological imaging and spectroscopic applications); and (2) Signal Amplification by Reversible Exchange ("SABRE"), a chemical process where organometallic catalysts are used to transfer the high nuclear spin order of para-hydrogen to molecular agents for applications—including for ultimate use as metabolic MRI contrast agents to probe responses to treatment of various diseases.
A.B., Princeton University
Ph.D., University of California, Berkeley
Postdoctoral Scholar, NSF Laboratory for Molecular Sciences at the California Institute of Technology
Inductee, National Academy of Inventors, SIUC Chapter (2017)
CURCA Award of Distinction, Center for Undergraduate Research & Creative Activities, SIUC (2017)
Kaplan Award for Research, Sigma Xi Society, SIUC Chapter (2015)
Cottrell Scholar Award (2005)
NSF Career Award (2004-2009)
Ralph E. Powe Junior Faculty Enhancement Award, Oak Ridge Associated Universities (2003)
Research Innovation Award, Research Corporation (2002)
Eastman Fellowship, Physical Chemistry, Eastman Chemical Company (1998-1999)
Robert Thornton McKay Prize in Physical Chemistry, Princeton University (1995)
Selected Recent Publications
“Near-unity nuclear polarization with an ‘open-source’ 129Xe
“A 3D-Printed High Power Nuclear Spin Polarizer.” P. Nikolaou, A.M. Coffey, L. L. Walkup, B.M. Gust, C.D. LaPierre, E. Koehnemann, M.J. Barlow, M.S. Rosen, B.M. Goodson, E.Y. Chekmenev, J. Am. Chem. Soc. 136, 1636−1642 (2014) (dx.doi.org/10.1021/ja412093d); Highlighted in JACS Spotlight: "Printing Scientific Instruments on Demand" (Berg, E.G.) dx.doi.org/10.1021/ja500981a, 136, 1681−1681 (2014).
“Heterogeneous Solution NMR Signal Enhancement by Reversible Exchange (HET-SABRE).” F. Shi, A.M. Coffey, K.W. Waddell, E.Y. Chekmenev, and B.M. Goodson, Angew. Chem. Int. Ed. Engl. DOI: 10.1002 /
“Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility of NMR Signal Amplification by Reversible Exchange.” Milton L. Truong, Fan Shi, Ping He, Bingxin Yuan, Kyle N. Plunkett, Aaron M. Coffey, Danila A. Barskiy, Kirill V. Kovtunov, Igor V. Koptyug, Kevin W. Waddell, Boyd M. Goodson, and Eduard Y. Chekmenev, J. Phys. Chem. B, published online November 2014; 118 (48) Pages: 13882-13889 (2014).
“Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization.” Thomas Theis, Milton Truong, Aaron M. Coffey, Kevin Waddell, Fan Shi, Boyd Goodson, Warren S. Warren, and Eduard Y. Chekmenev, J. Am. Chem. Soc., DOI: 10.1021/ja512242d; published online Jan. 15, 2015; 137, 1404−1407 (2015).
“Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange.” Fan Shi, Aaron M. Coffey, Kevin W. Waddell, Eduard Y. Chekmenev, and Boyd M. Goodson. J. Phys. Chem. C, DOI: 10.1021/acs.jpcc.5b02036, published online March 11, 2015; 119, 7525-7533 (2015).
"Aqueous NMR Signal Enhancement by Reversible Exchange in a Single Step Using Water-Soluble Catalysts” Fan Shi, Ping He, Quinn Best, Kirsten Groome, Milton L. Truong, Aaron M. Coffey, Greg Zimay, Roman V. Shchepin, Kevin Waddell, Eduard Y. Chekmenev, and Boyd M. Goodson, J. Phys. Chem. C. 120, 12149–12156 (2016).
“Over 20% 15N Hyperpolarization in Under One Minute for Metronidazole, an Antibiotic and Hypoxia Probe.” D.A. Barskiy, R.V. Shchepin, A.M. Coffey, T. Theis, W.S. Warren, B.M. Goodson, and E.Y. Chekmenev, J. Am. Chem. Soc. DOI: 10.1021/jacs.6b04784, 138, 8080–8083 (2016).
“Aqueous, Heterogeneous Parahydrogen-Induced 15N Polarization.” Liana B. Bales, Kirill V. Kovtunov, Danila A. Barskiy, Roman V. Shchepin, Aaron M. Coffey, Larisa M. Kovtunova, Andrey V. Bukhtiyarov, Matthew Feldman, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, and Boyd M. Goodson. J. Phys. Chem. C, DOI: 10.1021/acs.jpcc.7b05912, published online June 21, 121, 15304–15309 (2017).
“Heterogeneous Microtesla SABRE Enhancement of 15N NMR Signals.” Kirill V. Kovtunov, Larisa M. Kovtunova, Max E. Gemeinhardt, Andrey V. Bukhtiyarov, Jonathan Gesiorski, Valerii I. Bukhtiyarov, Eduard Y. Chekmenev, Igor V. Koptyug, Boyd M. Goodson. Angew. Chem. Intl. Ed., DOI: 10.1002/anie.201705014, published online June 23, 56, 10433 –10437 (2017).