Current Research Areas| Chemistry and Biochemistry | SIU

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Current Research Areas

Medicinal

 Our research team has found that the (+) and (-) enantiomers. respectively, of cis-bisdehyrodoisynolic acid (Z-BDDA) have specific physiological effects in males and females. The (+) enantiomer is very effective in reducing enlarged prostates (BPH) and shows excellent anti-prostate-cancer activity, with very little of the feminizing side effects commonly derived from prostate-cancer therapy. Our studies of the estrogenic carboxylic acids will be  continued for the ongoing in vivo and in vitro (cell-line and receptor-binding) investigations being carried out by the Institute's physiology collaborators in the School of Medicine and College of Agriculture.  We have developed syntheses of the enantiomeric cis-bisdehydrodoisynolic acids and 2-methoxyestradiol.  More recently, our collaborators in anatomy and animal science provided strong evidence that neurological recovery from traumatic brain injury is facilitated by (±)-Z-BDDA.    

Chemistry of Hypervalent Iodine Compounds

Hypervalent iodine chemistry has attracted much attention among chemistry community because their versatility, low toxicity, and air- and water-stability.  We are interested in the mechanistic as well as synthetic aspect of these compounds, particularly in the use of these compounds to make heterocylic compounds with or without transition metal catalysis.