Current research interests of the Goodson Group: NMR and MRI enjoy wide applicability but suffer from poor detection sensitivity. For this reason, imaging and spectroscopy of low-concentration species—such as gases in lung spaces or metabolites in tissues—can be particularly challenging. To combat such problems, we are pursuing two “hyperpolarization” methods: (1) spin-exchange optical pumping (SEOP), a technique whereby high-power lasers are used to prepare hyperpolarized noble gases (primarily for enhanced biological imaging and spectroscopic applications); and (2) Signal Amplification by Reversible Exchange ("SABRE"), a chemical process where organometallic catalysts are used to transfer the high nuclear spin order of para-hydrogen to molecular agents for applications—including for ultimate use as metabolic MRI contrast agents to probe responses to treatment of various diseases.
A.B., Princeton University
Ph.D., University of California, Berkeley
Postdoctoral Scholar, NSF Laboratory for Molecular Sciences at the California Institute of Technology
Kaplan Award for Research, Sigma Xi Society, SIUC Chapter (2015)
Cottrell Scholar Award (2005)
NSF Career Award (2004-2009)
Ralph E. Powe Junior Faculty Enhancement Award, Oak Ridge Associated Universities (2003)
Research Innovation Award, Research Corporation (2002)
Eastman Fellowship, Physical Chemistry, Eastman Chemical Company (1998-1999)
Robert Thornton McKay Prize in Physical Chemistry, Princeton University (1995)
“Hyperpolarization Methods for MRS.” B.M. Goodson, N. Whiting, A.M. Coffey, P. Nikolaou, F. Shi, B.M. Gust, M.E. Gemeinhardt, R.V. Shchepin, J.G. Skinner, J.R. Birchall, M.J. Barlow, E.Y. Chekmenev, eMagRes; Vol 4: 797-810. DOI 10.1002/9780470034590.emrstm1457 (2015).
"NMR Signal Amplification by Reversible Exchange of Neat Liquids." R.V. Shchepin, M.L. Truong, T. Theis, A.M. Coffey, K.W. Waddell, F. Shi, W.S. Warren, B.M. Goodson, E.Y. Chekmenev, J. Phys. Chem. Lett., 6, 1961−1967 (2015).
“Spin-Exchange Optical Pumping at High Xenon Densities and Laser Fluxes: Principles and Practice.” B.M. Goodson, N. Whiting, H. Newton, J.G. Skinner, K. Ranta, P. Nikolaou, M.J. Barlow, E.Y. Chekmenev, in: Hyperpolarized Xenon-129 Magnetic Resonance; T. Meersmann and E. Brunner, Eds., pp. 96-121 New Developments in NMR No. 4, RSC Publishing (2015).
"15N Hyperpolarization By Reversible Exchange Using SABRE-SHEATH." M.L. Truong, T. Theis, A.M. Coffey, R.V. Shchepin, K.W. Waddell, F. Shi, B.M. Goodson, W.S. Warren, E.Y. Chekmenev, J. Phys. Chem. C., 119, 8786−8797 (2015).
“Nanoscale Catalysts for NMR Signal Enhancement by Reversible Exchange.” F. Shi, A.M. Coffey, K.W. Waddell, E.Y. Chekmenev, B.M. Goodson. J. Phys. Chem. C, 119, 7525-7533 (2015).
“Microtesla SABRE Enables 10% Nitrogen-15 Nuclear Spin Polarization.” T. Theis, M. Truong, A.M. Coffey, K. Waddell, F. Shi, B. Goodson, W.S. Warren, E.Y. Chekmenev, J. Am. Chem. Soc., 137, 1404−1407 (2015).
“NMR Hyperpolarization Techniques for Biomedicine.” P. Nikolaou, B.M. Goodson, E.Y. Chekmenev, Chem. Eur. J. 21, 3156-3166 (2015).
“Irreversible Catalyst Activation Enables Hyperpolarization and Water Solubility of NMR Signal Amplification by Reversible Exchange.” M.L. Truong, F. Shi, P. He, B. Yuan, K.N. Plunkett, A.M. Coffey, D.A. Barskiy, K.V. Kovtunov, I.V. Koptyug, K.W. Waddell, B.M. Goodson, E.Y. Chekmenev, J. Phys. Chem. B, 118, 13882-13889 (2014).
“In situ and Ex situ Low-field NMR and MRI Endowed by SABRE Hyperpolarization.” D.A. Barskiy, K.V. Kovtunov, I.V. Koptyug, P.He, K.A. Groome, Q.A. Best, F. Shi, B.M. Goodson, R.V. Shchepin, M.L. Truong, A.M. Coffey, K.W. Waddell, E.Y. Chekmenev, Chem. Phys. Chem., 15, 4100-4107 (2014).
“High-Resolution Low-field Molecular Magnetic Resonance Imaging of Hyperpolarized Liquids”, A. Coffey; K. Kovtunov D. Barskiy; I. Koptyug; R. Shchepin; K. Waddell; P. He; K. Groome; Q. Best; F. Shi; B.M. Goodson; E.Y. Chekmenev, Anal. Chem. 86, 9042−9049 (2014).