Keith Gagnon | Chemistry and Biochemistry | SIU

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Keith Gagnon

Assistant Professor

Keith Gagnon

Phone: 618-453-3895
ktgagnon@siu.edu  

Gagnon Lab Webpage

Molecular mechanisms of human neurological repeat expansion disorders.

Roles of noncoding RNA in human biology and disease.

Education

B.S., North Carolina State University
Ph.D., North Carolina State University
Postdoc, UT Southwestern Medical Center, Depts of Pharmacology and Biochemistry

Awards

NIH National Research Service Award (F32), Ruth L. Kirschstein Fellow (2009-2012)
A.R. Main-Becton Dickinson Award for Outstanding Graduate Research (2007)

Selected Publications

Gagnon, K.T., Li, L., Chu, Y., Janowski, B.A., and Corey, D.R. (2014) RNAi Factors Are Present and Active in Human Cell Nuclei. Cell Reports, 6:211-221.

Matsui, M., Zhang, H., Chu, J., Gagnon, K.T., Shaikh, S., Kuchimanchi, S., Manoharan, M., Corey, D.R., and Janowski, B.A. (2013) Promoter RNA Links Transcriptional Regulation of Inflammatory Pathway Genes. Nucl. Acids Res., 41:10086-10109.

Dodd, D.W., Gagnon, K.T., and Corey, D.R. (2013) Digital Quantitation of Potential Therapeutic Target RNAs. Nucl. Acid Therap., 23:188-194.

Gagnon, K.T., Biswas, S., Zhang, X., Brown, B.A. II, Wollenzien, P., Mattos, C., and Maxwell, E.S (2012) Structurally Conserved Nop56/58 N-Terminal Domain Facilitates Efficient Box C/D Ribonucleoprotein-guided Methyltransferase Activity. J. Biol. Chem., 287:19418-19428.

Gagnon, K.T., Watts, J.K., Pendergraff, H.M., Potier, P., Thai, D., Montaillier, C., and Corey, D.R. (2011) Antisense and antigene inhibition of gene expression by cell-permeable oligonucleotideoligospermine conjugates. J. Am. Chem. Soc., 133:8404-8407.

Biswas, S., Buhrman, G., Gagnon, K.T., Mattos, C., Brown II, B.A., and Maxwell, E.S. (2011) Comparative Analysis of the 15.5kD Box C/D snoRNP Core Protein in the Primitive Eukaryote Giardia lamblia Reveals Unique Structural and Functional Features. Biochemistry, 50:2907-2918.

Hu, J., Gagnon, K.T., Lui, J., Watts, J.K., Syeda-Newaz, J., Bennett, C.F., Swayze, E.E., Randolph, J., Chattopadhyaya, J. and Corey, D.R. (2011) Allele-selective inhibition of ataxin-3 (ATX3) expression by antisense oligomers and duplex RNAs. Biol. Chem., 392:315-325.

Gagnon, K.T., Pendergraff, H.M., Deleavey, G.F., Swayze, E.E., Potier, P., Randolph, J., Roesch, E.B., Chattopadhyaya, J., Damha, M.J., Bennett, C.F., Montaillier, C., Lemaitre, M., and Corey, D.R. (2010) Allele-Selective Inhibition of Mutant Huntingtin Expression with Antisense Oligonucleotides Targeting the Expanded CAG Repeat. Biochemistry, 49:10166-10178.

Yue, X., Schwartz, J. C., Chu, Y., Younger, S. T., Gagnon, K.T., Elbashir, S., Janowski, B. A., and Corey, D. R. (2010) Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini. Nat. Chem. Biol., 6:621-629.

Gagnon, K.T., Zhang, X., Qu, G., Biswas, S., Suryadi, J., Brown II, B.A., and Maxwell, E.S. (2010) Signature Amino Acids Enable the Archaeal L7Ae Box C/D RNP Core Protein to Recognize and Bind the K-loop RNA Motif. RNA, 16:79-90.

Bleichert, F., Gagnon, K.T., Brown II, B.A., Maxwell, E.S., Leschziner, A.E., Unger, V.M., and Baserga, S.J. (2009) A Dimeric Structure for Archaeal Box C/D Small Ribonucleoproteins. Science, 325(5946):1384-1387.

Gagnon, K.T., Ju, S.Y., Goshe, M.B., Maxwell, E.S., and Franzen, S. (2009) A Role for Hydrophobicity in a Diels-Alder Reaction Catalyzed by Pyridyl-Modified RNA. Nucl. Acids Res., 37(9):3074-3082.

Hu, J., Matsui, M., Gagnon, K.T., Schwartz, J.C., Gabillet, S., Arar, K., Wu, J., Bezprozvanny, I., and Corey, D.R. (2009) Allele-Specific Silencing of Mutant Huntingtin and Ataxin-3 Genes by Targeting Expanded CAG Repeats in mRNAs. Nat. Biotechnol., 27(5):478-484.

Gagnon, K.T., Zhang, X., Agris, P.F., and Maxwell, E.S. (2006) Assembly of the Archaeal Box C/D sRNP Can Occur Via Alternative Pathways and Requires Temperature-Facilitated sRNA Remodeling. J. Mol. Biol., 362(5):1025-1042.